Correlation of epigenetic change and identification of risk factors for oral submucous fibrosis.
Identifieur interne : 000291 ( Main/Exploration ); précédent : 000290; suivant : 000292Correlation of epigenetic change and identification of risk factors for oral submucous fibrosis.
Auteurs : Chunjiao Xu [République populaire de Chine] ; Jing Zhao ; Wings T Y. Loo ; Liang Hao ; Min Wang ; Mary N B. Cheung ; Yiding Dou ; Adrian Y S. Yip ; Elizabeth L Y. Ng ; Louis W C. Chow ; Qing LiuSource :
- The International journal of biological markers [ 1724-6008 ] ; 2012.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Cadhérines (génétique), Carcinome épidermoïde (génétique), Carcinome épidermoïde de la tête et du cou (MeSH), Cyclooxygenase 2 (génétique), Facteurs de risque (MeSH), Femelle (MeSH), Fibrose buccale sous-muqueuse (génétique), Humains (MeSH), Jeune adulte (MeSH), Mâle (MeSH), Méthylation de l'ADN (MeSH), Prédisposition génétique à une maladie (MeSH), Sujet âgé (MeSH), Tumeurs de la bouche (génétique), Tumeurs de la tête et du cou (génétique), Épigenèse génétique (MeSH), États précancéreux (génétique), Études cas-témoins (MeSH).
- MESH :
- génétique : Cadhérines, Carcinome épidermoïde, Cyclooxygenase 2, Fibrose buccale sous-muqueuse, Tumeurs de la bouche, Tumeurs de la tête et du cou, États précancéreux.
- Adulte, Adulte d'âge moyen, Carcinome épidermoïde de la tête et du cou, Facteurs de risque, Femelle, Humains, Jeune adulte, Mâle, Méthylation de l'ADN, Prédisposition génétique à une maladie, Sujet âgé, Épigenèse génétique, Études cas-témoins.
English descriptors
- KwdEn :
- Adult (MeSH), Aged (MeSH), Cadherins (genetics), Carcinoma, Squamous Cell (genetics), Case-Control Studies (MeSH), Cyclooxygenase 2 (genetics), DNA Methylation (MeSH), Epigenesis, Genetic (MeSH), Female (MeSH), Genetic Predisposition to Disease (MeSH), Head and Neck Neoplasms (genetics), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Mouth Neoplasms (genetics), Oral Submucous Fibrosis (genetics), Precancerous Conditions (genetics), Risk Factors (MeSH), Squamous Cell Carcinoma of Head and Neck (MeSH), Young Adult (MeSH).
- MESH :
- chemical , genetics : Cadherins, Cyclooxygenase 2.
- genetics : Carcinoma, Squamous Cell, Head and Neck Neoplasms, Mouth Neoplasms, Oral Submucous Fibrosis, Precancerous Conditions.
- Adult, Aged, Case-Control Studies, DNA Methylation, Epigenesis, Genetic, Female, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Risk Factors, Squamous Cell Carcinoma of Head and Neck, Young Adult.
Abstract
BACKGROUND
DNA methylation of certain genes is an epigenetic change that is essential for tumorigenesis. Oral submucous fibrosis (OSF) is a precancerous condition of oral mucosa with inflammation and progressive fibrosis of the lamina propria and deeper connective tissue. The hypermethylation of E-cadherin and cyclooxygenase 2 (COX-2) in chronic inflammation may demonstrate a mild lesion/mutation at epigenetic levels. This study compares the hypermethylation status of E-cadherin and COX-2 genes in patients with oral cancer and patients with OSF and also aims to identify risk factors for the development of OSF.
METHODS
DNA was extracted from blood samples of 50 healthy subjects, 50 patients with OSF and 60 patients with oral cancer. Methylation-specific polymerase chain reaction for E-cadherin and COX-2 was performed on these samples and the products were analyzed on 2% agarose gel. Surveys about oral health habits and clinical periodontal examinations in patients with OSF and healthy subjects were also conducted by well-trained dentists, and logistic regression was performed to identify risk factors for OSF.
RESULTS
Hypermethylation of E-cadherin and COX-2 was observed in 36% and 22% of oral cancer samples, respectively. In patients with OSF, the rates were 52% and 30%, and in healthy controls the rates were 4% and 6%. Hypermethylation was shown to be correlated between the 3 groups with statistical significance (p<0.01). Methylation of CpG islands in E-cadherin and COX-2 occurred more frequently in patients with OSF than in the control group, but less frequently than in patients with oral cancer. In the logistic regression analysis, smoking, brushing more than twice daily, periodontal probing depth and plaque index were identified as 4 major risk factors for OSF.
CONCLUSIONS
These data confirm that E-cadherin and COX-2 expressions are related to OSF. The epigenetic changes presented in patients with chronic inflammation might demonstrate an irreversible destruction in the tissues or organs similar to the effects of cancer. Chronic OSF was significantly associated with hypermethylation, a cancer risk factor.
DOI: 10.5301/JBM.2012.9937
PubMed: 23250779
Affiliations:
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Loo</name></author><author><name sortKey="Hao, Liang" sort="Hao, Liang" uniqKey="Hao L" first="Liang" last="Hao">Liang Hao</name></author><author><name sortKey="Wang, Min" sort="Wang, Min" uniqKey="Wang M" first="Min" last="Wang">Min Wang</name></author><author><name sortKey="Cheung, Mary N B" sort="Cheung, Mary N B" uniqKey="Cheung M" first="Mary N B" last="Cheung">Mary N B. Cheung</name></author><author><name sortKey="Dou, Yiding" sort="Dou, Yiding" uniqKey="Dou Y" first="Yiding" last="Dou">Yiding Dou</name></author><author><name sortKey="Yip, Adrian Y S" sort="Yip, Adrian Y S" uniqKey="Yip A" first="Adrian Y S" last="Yip">Adrian Y S. Yip</name></author><author><name sortKey="Ng, Elizabeth L Y" sort="Ng, Elizabeth L Y" uniqKey="Ng E" first="Elizabeth L Y" last="Ng">Elizabeth L Y. Ng</name></author><author><name sortKey="Chow, Louis W C" sort="Chow, Louis W C" uniqKey="Chow L" first="Louis W C" last="Chow">Louis W C. Chow</name></author><author><name sortKey="Liu, Qing" sort="Liu, Qing" uniqKey="Liu Q" first="Qing" last="Liu">Qing Liu</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:23250779</idno><idno type="pmid">23250779</idno><idno type="doi">10.5301/JBM.2012.9937</idno><idno type="wicri:Area/Main/Corpus">000260</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000260</idno><idno type="wicri:Area/Main/Curation">000260</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000260</idno><idno type="wicri:Area/Main/Exploration">000260</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Correlation of epigenetic change and identification of risk factors for oral submucous fibrosis.</title><author><name sortKey="Xu, Chunjiao" sort="Xu, Chunjiao" uniqKey="Xu C" first="Chunjiao" last="Xu">Chunjiao Xu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Periodontology and Oral Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, PR China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Periodontology and Oral Medicine, Xiangya Hospital, Central South University, Changsha, Hunan</wicri:regionArea><wicri:noRegion>Hunan</wicri:noRegion></affiliation></author><author><name sortKey="Zhao, Jing" sort="Zhao, Jing" uniqKey="Zhao J" first="Jing" last="Zhao">Jing Zhao</name></author><author><name sortKey="Loo, Wings T Y" sort="Loo, Wings T Y" uniqKey="Loo W" first="Wings T Y" last="Loo">Wings T Y. Loo</name></author><author><name sortKey="Hao, Liang" sort="Hao, Liang" uniqKey="Hao L" first="Liang" last="Hao">Liang Hao</name></author><author><name sortKey="Wang, Min" sort="Wang, Min" uniqKey="Wang M" first="Min" last="Wang">Min Wang</name></author><author><name sortKey="Cheung, Mary N B" sort="Cheung, Mary N B" uniqKey="Cheung M" first="Mary N B" last="Cheung">Mary N B. Cheung</name></author><author><name sortKey="Dou, Yiding" sort="Dou, Yiding" uniqKey="Dou Y" first="Yiding" last="Dou">Yiding Dou</name></author><author><name sortKey="Yip, Adrian Y S" sort="Yip, Adrian Y S" uniqKey="Yip A" first="Adrian Y S" last="Yip">Adrian Y S. Yip</name></author><author><name sortKey="Ng, Elizabeth L Y" sort="Ng, Elizabeth L Y" uniqKey="Ng E" first="Elizabeth L Y" last="Ng">Elizabeth L Y. Ng</name></author><author><name sortKey="Chow, Louis W C" sort="Chow, Louis W C" uniqKey="Chow L" first="Louis W C" last="Chow">Louis W C. Chow</name></author><author><name sortKey="Liu, Qing" sort="Liu, Qing" uniqKey="Liu Q" first="Qing" last="Liu">Qing Liu</name></author></analytic><series><title level="j">The International journal of biological markers</title><idno type="eISSN">1724-6008</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Cadherins (genetics)</term><term>Carcinoma, Squamous Cell (genetics)</term><term>Case-Control Studies (MeSH)</term><term>Cyclooxygenase 2 (genetics)</term><term>DNA Methylation (MeSH)</term><term>Epigenesis, Genetic (MeSH)</term><term>Female (MeSH)</term><term>Genetic Predisposition to Disease (MeSH)</term><term>Head and Neck Neoplasms (genetics)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Mouth Neoplasms (genetics)</term><term>Oral Submucous Fibrosis (genetics)</term><term>Precancerous Conditions (genetics)</term><term>Risk Factors (MeSH)</term><term>Squamous Cell Carcinoma of Head and Neck (MeSH)</term><term>Young Adult (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Cadhérines (génétique)</term><term>Carcinome épidermoïde (génétique)</term><term>Carcinome épidermoïde de la tête et du cou (MeSH)</term><term>Cyclooxygenase 2 (génétique)</term><term>Facteurs de risque (MeSH)</term><term>Femelle (MeSH)</term><term>Fibrose buccale sous-muqueuse (génétique)</term><term>Humains (MeSH)</term><term>Jeune adulte (MeSH)</term><term>Mâle (MeSH)</term><term>Méthylation de l'ADN (MeSH)</term><term>Prédisposition génétique à une maladie (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Tumeurs de la bouche (génétique)</term><term>Tumeurs de la tête et du cou (génétique)</term><term>Épigenèse génétique (MeSH)</term><term>États précancéreux (génétique)</term><term>Études cas-témoins (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cadherins</term><term>Cyclooxygenase 2</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Carcinoma, Squamous Cell</term><term>Head and Neck Neoplasms</term><term>Mouth Neoplasms</term><term>Oral Submucous Fibrosis</term><term>Precancerous Conditions</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Cadhérines</term><term>Carcinome épidermoïde</term><term>Cyclooxygenase 2</term><term>Fibrose buccale sous-muqueuse</term><term>Tumeurs de la bouche</term><term>Tumeurs de la tête et du cou</term><term>États précancéreux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Case-Control Studies</term><term>DNA Methylation</term><term>Epigenesis, Genetic</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Risk Factors</term><term>Squamous Cell Carcinoma of Head and Neck</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Carcinome épidermoïde de la tête et du cou</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Méthylation de l'ADN</term><term>Prédisposition génétique à une maladie</term><term>Sujet âgé</term><term>Épigenèse génétique</term><term>Études cas-témoins</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>DNA methylation of certain genes is an epigenetic change that is essential for tumorigenesis. Oral submucous fibrosis (OSF) is a precancerous condition of oral mucosa with inflammation and progressive fibrosis of the lamina propria and deeper connective tissue. The hypermethylation of E-cadherin and cyclooxygenase 2 (COX-2) in chronic inflammation may demonstrate a mild lesion/mutation at epigenetic levels. This study compares the hypermethylation status of E-cadherin and COX-2 genes in patients with oral cancer and patients with OSF and also aims to identify risk factors for the development of OSF.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>DNA was extracted from blood samples of 50 healthy subjects, 50 patients with OSF and 60 patients with oral cancer. Methylation-specific polymerase chain reaction for E-cadherin and COX-2 was performed on these samples and the products were analyzed on 2% agarose gel. Surveys about oral health habits and clinical periodontal examinations in patients with OSF and healthy subjects were also conducted by well-trained dentists, and logistic regression was performed to identify risk factors for OSF.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Hypermethylation of E-cadherin and COX-2 was observed in 36% and 22% of oral cancer samples, respectively. In patients with OSF, the rates were 52% and 30%, and in healthy controls the rates were 4% and 6%. Hypermethylation was shown to be correlated between the 3 groups with statistical significance (p<0.01). Methylation of CpG islands in E-cadherin and COX-2 occurred more frequently in patients with OSF than in the control group, but less frequently than in patients with oral cancer. In the logistic regression analysis, smoking, brushing more than twice daily, periodontal probing depth and plaque index were identified as 4 major risk factors for OSF.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>These data confirm that E-cadherin and COX-2 expressions are related to OSF. The epigenetic changes presented in patients with chronic inflammation might demonstrate an irreversible destruction in the tissues or organs similar to the effects of cancer. Chronic OSF was significantly associated with hypermethylation, a cancer risk factor.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23250779</PMID><DateCompleted><Year>2013</Year><Month>09</Month><Day>05</Day></DateCompleted><DateRevised><Year>2019</Year><Month>02</Month><Day>21</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1724-6008</ISSN><JournalIssue CitedMedium="Internet"><Volume>27</Volume><Issue>4</Issue><PubDate><Year>2012</Year><Month>Dec</Month><Day>27</Day></PubDate></JournalIssue><Title>The International journal of biological markers</Title><ISOAbbreviation>Int J Biol Markers</ISOAbbreviation></Journal><ArticleTitle>Correlation of epigenetic change and identification of risk factors for oral submucous fibrosis.</ArticleTitle><Pagination><MedlinePgn>e314-21</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.5301/JBM.2012.9937</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">DNA methylation of certain genes is an epigenetic change that is essential for tumorigenesis. Oral submucous fibrosis (OSF) is a precancerous condition of oral mucosa with inflammation and progressive fibrosis of the lamina propria and deeper connective tissue. The hypermethylation of E-cadherin and cyclooxygenase 2 (COX-2) in chronic inflammation may demonstrate a mild lesion/mutation at epigenetic levels. This study compares the hypermethylation status of E-cadherin and COX-2 genes in patients with oral cancer and patients with OSF and also aims to identify risk factors for the development of OSF.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">DNA was extracted from blood samples of 50 healthy subjects, 50 patients with OSF and 60 patients with oral cancer. Methylation-specific polymerase chain reaction for E-cadherin and COX-2 was performed on these samples and the products were analyzed on 2% agarose gel. Surveys about oral health habits and clinical periodontal examinations in patients with OSF and healthy subjects were also conducted by well-trained dentists, and logistic regression was performed to identify risk factors for OSF.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Hypermethylation of E-cadherin and COX-2 was observed in 36% and 22% of oral cancer samples, respectively. In patients with OSF, the rates were 52% and 30%, and in healthy controls the rates were 4% and 6%. Hypermethylation was shown to be correlated between the 3 groups with statistical significance (p<0.01). Methylation of CpG islands in E-cadherin and COX-2 occurred more frequently in patients with OSF than in the control group, but less frequently than in patients with oral cancer. In the logistic regression analysis, smoking, brushing more than twice daily, periodontal probing depth and plaque index were identified as 4 major risk factors for OSF.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These data confirm that E-cadherin and COX-2 expressions are related to OSF. The epigenetic changes presented in patients with chronic inflammation might demonstrate an irreversible destruction in the tissues or organs similar to the effects of cancer. Chronic OSF was significantly associated with hypermethylation, a cancer risk factor.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Chunjiao</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Periodontology and Oral Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhao</LastName><ForeName>Jing</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Loo</LastName><ForeName>Wings T Y</ForeName><Initials>WT</Initials></Author><Author ValidYN="Y"><LastName>Hao</LastName><ForeName>Liang</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Min</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Cheung</LastName><ForeName>Mary N B</ForeName><Initials>MN</Initials></Author><Author ValidYN="Y"><LastName>Dou</LastName><ForeName>Yiding</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Yip</LastName><ForeName>Adrian Y S</ForeName><Initials>AY</Initials></Author><Author ValidYN="Y"><LastName>Ng</LastName><ForeName>Elizabeth L Y</ForeName><Initials>EL</Initials></Author><Author ValidYN="Y"><LastName>Chow</LastName><ForeName>Louis W C</ForeName><Initials>LW</Initials></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Qing</ForeName><Initials>Q</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>12</Month><Day>27</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Int J Biol Markers</MedlineTA><NlmUniqueID>8712411</NlmUniqueID><ISSNLinking>0393-6155</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015820">Cadherins</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.14.99.1</RegistryNumber><NameOfSubstance UI="D051546">Cyclooxygenase 2</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015820" MajorTopicYN="N">Cadherins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002294" MajorTopicYN="N">Carcinoma, Squamous Cell</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051546" MajorTopicYN="N">Cyclooxygenase 2</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019175" MajorTopicYN="Y">DNA Methylation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D044127" MajorTopicYN="N">Epigenesis, Genetic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020022" MajorTopicYN="N">Genetic Predisposition to Disease</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006258" MajorTopicYN="N">Head and Neck Neoplasms</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009062" MajorTopicYN="N">Mouth Neoplasms</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009914" MajorTopicYN="N">Oral Submucous Fibrosis</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011230" MajorTopicYN="N">Precancerous Conditions</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000077195" MajorTopicYN="N">Squamous Cell Carcinoma of Head and Neck</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="accepted"><Year>2012</Year><Month>09</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>12</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>12</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>9</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23250779</ArticleId><ArticleId IdType="pii">FC5C042D-91F2-4998-B824-E2063B1EF62A</ArticleId><ArticleId IdType="doi">10.5301/JBM.2012.9937</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Cheung, Mary N B" sort="Cheung, Mary N B" uniqKey="Cheung M" first="Mary N B" last="Cheung">Mary N B. Cheung</name><name sortKey="Chow, Louis W C" sort="Chow, Louis W C" uniqKey="Chow L" first="Louis W C" last="Chow">Louis W C. Chow</name><name sortKey="Dou, Yiding" sort="Dou, Yiding" uniqKey="Dou Y" first="Yiding" last="Dou">Yiding Dou</name><name sortKey="Hao, Liang" sort="Hao, Liang" uniqKey="Hao L" first="Liang" last="Hao">Liang Hao</name><name sortKey="Liu, Qing" sort="Liu, Qing" uniqKey="Liu Q" first="Qing" last="Liu">Qing Liu</name><name sortKey="Loo, Wings T Y" sort="Loo, Wings T Y" uniqKey="Loo W" first="Wings T Y" last="Loo">Wings T Y. Loo</name><name sortKey="Ng, Elizabeth L Y" sort="Ng, Elizabeth L Y" uniqKey="Ng E" first="Elizabeth L Y" last="Ng">Elizabeth L Y. Ng</name><name sortKey="Wang, Min" sort="Wang, Min" uniqKey="Wang M" first="Min" last="Wang">Min Wang</name><name sortKey="Yip, Adrian Y S" sort="Yip, Adrian Y S" uniqKey="Yip A" first="Adrian Y S" last="Yip">Adrian Y S. Yip</name><name sortKey="Zhao, Jing" sort="Zhao, Jing" uniqKey="Zhao J" first="Jing" last="Zhao">Jing Zhao</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Xu, Chunjiao" sort="Xu, Chunjiao" uniqKey="Xu C" first="Chunjiao" last="Xu">Chunjiao Xu</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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